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Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways

19 Jan 2023

Abstract excerpt

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma membrane (PM) macropores composed of gasdermin-family (GSDM) proteins. It facilitates two major functions in innate immunity: (i) elimination of intracellular replicative niches for pathogenic bacteria; and (ii) non-classical secretion of IL-1 family cytokines that amplify host-beneficial inflammatory responses to...

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PMID: 36656082
DOI: 10.1111/imr.13186

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