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Article

Caspase-11 Protects Against Bacteria That Escape the Vacuole

25 Jan 2013

Abstract excerpt

Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria. Although Salmonella typhimurium and...

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PMID: 23348507
DOI: 10.1126/science.1230751

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