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Article

IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis

1 Jun 2015

Abstract excerpt

The innate immune system is critical for host defense against microbial pathogens, yet many pathogens express virulence factors that impair immune function. Here, we used the bacterial pathogen Legionella pneumophila to understand how the immune system successfully overcomes pathogen subversion mechanisms. L. pneumophila replicates within macrophages by using a type IV secretion system to translocate bacterial...

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PMID: 26034289
DOI: 10.1073/pnas.1501289112

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