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Article

An Inflammatory Perspective on Necroptosis.

Molecular cell - 16 Mar 2017

Kearney Conor J, Martin Seamus J

Abstract excerpt

Necroptosis (programmed necrosis) occurs in response to TNF, Fas, or TRAIL, as well as certain TLR ligands, when caspase activity required for apoptosis is blocked. Necroptosis is typically considered a highly pro-inflammatory mode of cell death, due to release of intracellular "danger signals" that promote inflammation. However, because most pro-necroptotic stimuli are intrinsically highly pro-inflammatory-due...

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Source

Identifiers

PMID: 28306512
DOI: 10.1016/j.molcel.2017.02.024

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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