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Article

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Case Christopher L, Kohler Lara J, Lima Jonilson B, Strowig Till, de Zoete Marcel R, Flavell Richard A, Zamboni Dario S, Roy Craig R

Abstract excerpt

A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here we demonstrate that this pathway requires caspase-11. Treatment of macrophages with LPS up-regulated the host components required for this caspase-11 activation pathway. Activation by Legionella differed from caspase-11 activation using previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23307811
DOI: 10.1073/pnas.1211521110
PMCID: PMC3562791

Genes

NAIP
NLRC4
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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