Article

Accurate <i>de novo</i> design of high-affinity protein binding macrocycles using deep learning

2024-11-18

Abstract excerpt

<h4>ABSTRACT</h4> The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite considerable progress in physics-based methods for peptide design and deep-learning methods for protein design, there are currently no robust approaches for de novo design of protein-binding macrocycles...

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Literature Corpus work: 774b1209-c1b2-5b7c-829e-485e82b0cc18
DOI: 10.1101/2024.11.18.622547

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