Article

Peptide Design through Binding Interface Mimicry

2025-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Peptides offer distinct advantages for targeted therapy, including oral bioavailability, cellular permeability, and high specificity, which set them apart from conventional small molecules and biologics. In this work, we developed an AI algorithm, named PepMimic, to transform a known protein receptor or an existing antibody of a target into a short peptide drug by mimicking the binding interface...

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Identifiers and source

Literature Corpus work: 00fb01ce-5e8d-506f-aac4-ec71f2cf74c6
DOI: 10.1101/2025.01.21.634006

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