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Article

Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides.

Molecules (Basel, Switzerland) - 14 Dec 2019

Diller David J, Swanson Jon, Bayden Alexander S, Brown Chris J, Thean Dawn, Lane David P, Partridge Anthony W, Sawyer Tomi K, Audie Joseph

Abstract excerpt

There is interest in peptide drug design, especially for targeting intracellular protein-protein interactions. Therefore, the experimental validation of a computational platform for enabling peptide drug design is of interest. Here, we describe our peptide drug design platform (CMDInventus) and demonstrate its use in modeling and predicting the structural and binding aspects of diverse peptides that interact with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31847417
DOI: 10.3390/molecules24244586
PMCID: PMC6943714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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