Article

De novo design of high-affinity protein binders to bioactive helical peptides

2022-12-10

Abstract excerpt

Many peptide hormones form an alpha-helix upon binding their receptors 1–4 , and sensitive detection methods for them could contribute to better clinical management. De novo protein design can now generate binders with high affinity and specificity to structured proteins 5,6 . However, the design of interactions between proteins and short helical peptides is an unmet challenge. Here, we describe parametric gene...

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Literature Corpus work: fbd99dbe-a3f6-5da3-920d-257d49ccdeb8
DOI: 10.1101/2022.12.10.519862

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