Article

A practical workflow for CAR screening in primary T cells using fitness-guided design and mRNA electroporation

2026-07-29

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable therapeutic outcomes in hematological cancers. However, broader clinical use has uncovered substantial challenges arising from intrinsic properties of both T cells and tumor tissues. As the functional phenotype of CAR T cells is affected by the CAR molecular architecture, optimizing CAR constructs continues to be a critical and ongoing task. He...

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Literature Corpus work: 84e36df6-a692-5996-9de6-95c3a7e015c5
DOI: 10.64898/2026.07.28.741207

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