Article

Computational modeling and optimization of peptide-based CAR-T cell receptors targeting CD19 for enhanced efficacy and minimized toxicity

2025-03-14

Abstract excerpt

<title>Abstract</title> <p>Chimeric Antigen Receptor T-cell (CAR-T) therapy has revolutionized the treatment of B-cell malignancies, with CD19 being a primary target due to its stable expression in lymphomas. However, current CAR-T therapies face challenges related to antigen escape, treatment resistance, and toxicity. In this study, we employed a computational approach to design and optimize peptide-based CAR-T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6de54ab1-6534-5d75-90e3-fa1ba5a6af2c
DOI: 10.21203/rs.3.rs-6115435/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational modeling and optimization of peptide-based CAR-T cell receptors targeting CD19 for enhanced efficacy and minimized toxicityDOI 10.21203/rs.3.rs-6115435/v2Read

A CHIMERIC RECEPTOR ENABLING ANTIBODY-GUIDED RETARGETING OF CAR T- CELLSSemantic proximity Read

The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignanciesSemantic proximity Read

Chimeric antigen receptor-modified T cells strike backSemantic proximity Read

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptorsSemantic proximity Read

In silico and in vivo analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacySemantic proximity Read

CAR-T design: Elements and their synergistic functionSemantic proximity Read

Engineering next-generation chimeric antigen receptor-T cells: recent breakthroughs and remaining challenges in design and screening of novel chimeric antigen receptor variantsSemantic proximity Read

MiniCARbids: Minimalistic human binding domains specifically tailored to CAR T applicationsSemantic proximity Read

Computational structural optimization enhances IL13Rα2 – B7-H3 tandem CAR T cells to overcome antigen-heterogeneity-mediated tumor escapeSemantic proximity Read

Discovery 4.0: An Escape-Aware Computational Platform for Resistance-Proofed Chimeric Antigen Receptor DesignSemantic proximity Read

Fine Epitope Mapping of the CD19 Extracellular Domain Promotes Design.Semantic proximity Read

Refining chimeric antigen receptors via barcoded protein domain combination pooled screeningSemantic proximity Read