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A high throughput bispecific antibody discovery pipeline

7 Apr 2023

Abstract excerpt

Bispecific antibodies (BsAbs) represent an emerging class of immunotherapy, but inefficiency in the current discovery has limited their broad clinical availability. Here we report a high throughput, agnostic, single-cell-based functional screening pipeline, comprising molecular and cell engineering for efficient generation of BsAb library cells, followed by functional interrogation at the single-cell level to...

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PMID: 37029216
DOI: 10.1038/s42003-023-04746-w

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