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Article

Competing subclones and fitness diversity shape tumor evolution across cancer types.

Bioinformatics (Oxford, England) - 28 Feb 2026

Chen Hai, Shu Jingmin, Mudappathi Rekha, Li Elaine, Wang Panwen, Bergsagel Leif, Yang Ping, Sun Zhifu, Zhao Logan, Shi Changxin, Townsend Jeffrey P, Maley Carlo, Liu Li

Abstract excerpt

MOTIVATION: Intratumor heterogeneity arises from ongoing somatic evolution and complicates cancer diagnosis, prognosis, and treatment. Reconstructing evolutionary dynamics typically requires spatiotemporal samples, which are often unavailable in clinical settings. Computational approaches that can infer tumor evolutionary history from single-timepoint bulk sequencing data remain limited. RESULTS: We present...

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PMID: 41826799
DOI: 10.1093/bioinformatics/btag127
PMCID: PMC13025073

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