Article

Competing Subclones and Fitness Diversity Shape Tumor Evolution Across Cancer Types

2025-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Intratumor heterogeneity arises from ongoing somatic evolution complicating cancer diagnosis, prognosis, and treatment. Here we present TEATIME (es t imating e volution a ry events t hrough s i ngle-ti m epoint s e quencing), a novel computational framework that models tumors as mixtures of two competing cell populations: an ancestral clone with baseline fitness and a derived subclone wit...

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Literature Corpus work: 65cc660a-e6df-5265-85dc-4f7409a5c6d5
DOI: 10.1101/2025.05.31.657191

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