Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.

Cell - 9 Feb 2017

McGranahan Nicholas, Swanton Charles

Abstract excerpt

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to tumor evolution. We emphasize the importance of macro-evolutionary leaps, often involving large-scale chromosomal alterations, in driving tumor evolution...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Neoplasm
Share to Genetic Heterogeneity
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 28187284
DOI: 10.1016/j.cell.2017.01.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future.PMID 28187284Read ↗

Biological and therapeutic impact of intratumor heterogeneity in cancer evolution.Semantic proximity Read ↗

The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcomeSemantic proximity Read ↗

The microcosmos of intratumor heterogeneity: the space-time of cancer evolution.Semantic proximity Read ↗

Evolving concepts of tumor heterogeneitySemantic proximity Read ↗

Intratumor heterogeneity: evolution through space and time.Semantic proximity Read ↗

Tumor Evolutionary Principles: How Intratumor Heterogeneity Influences Cancer Treatment and Outcome.Semantic proximity Read ↗

Adapting clinical paradigms to the challenges of cancer clonal evolution.Semantic proximity Read ↗

The intricate dance of tumor evolution: Exploring immune escape, tumor migration, drug resistance, and treatment strategies.Semantic proximity Read ↗

Clinical implications of intratumor heterogeneity: challenges and opportunities.Semantic proximity Read ↗

Emerging trends and converging evidence in tumor evolution: A comprehensive review.Semantic proximity Read ↗

Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.Semantic proximity Read ↗

Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.