Article
Metabolic alterations and hepatitis C: From bench to bedside.
World journal of gastroenterology - 28 Jan 2016
Chang Ming-Ling
Abstract excerpt
In addition to causing cirrhosis and hepatocellular carcinoma, hepatitis C virus (HCV) is thought to cause hypolipidemia, hepatic steatosis, insulin resistance, metabolic syndrome, and diabetes. The viral life cycle of HCV depends on cholesterol metabolism in host cells. HCV core protein and nonstructural protein 5A perturb crucial lipid and glucose pathways, such as the sterol regulatory element-binding protein...
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