Article

Glioblastoma cells use an integrin- and CD44-mediated motor-clutch mode of migration in brain tissue

2023-10-25

Abstract excerpt

<h4>Summary</h4> Glioblastoma (GBM) is an aggressive malignant brain tumor with 2-year survival rates of 6.7% [1], [2]. One key characteristic of the disease is the ability of glioblastoma cells to migrate rapidly and spread throughout healthy brain tissue[3], [4]. To develop treatments that effectively target cell migration, it is important to understand the fundamental mechanism driving cell migration in brain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 772f3aeb-e44e-5474-b4c3-bfab9c94d49a
DOI: 10.1101/2023.10.23.563458

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glioblastoma cells use an integrin- and CD44-mediated motor-clutch mode of migration in brain tissueDOI 10.1101/2023.10.23.563458Read

Glioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain TissueSemantic proximity Read

Cell migration simulator-based biomarkers for glioblastomaSemantic proximity Read

Differential migration mechanics and immune responses of glioblastoma subtypesSemantic proximity Read

Traction force dynamics during patient-derived glioblastoma neurosphere invasion in 3D MatrigelSemantic proximity Read

Role of key genetic mutations on increasing migration of brain cancer cells through confinement.Semantic proximity Read

A human iPSC-based neural spheroid platform for modeling glioblastoma infiltration using high-content imagingSemantic proximity Read

Guidance receptor-mediated mechanocompliance of GBM cells facilitates immune-silent invasionSemantic proximity Read

<i>Ex vivo</i> dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypesSemantic proximity Read

Choice of Animal Models to Investigate Cell Migration and Invasion in GlioblastomaSemantic proximity Read

Interplay of Glioblastoma Cells with Microglia Shapes Invasive Phenotypes during Long-distance Invasion.Semantic proximity Read

Spatiotemporal Insights into Glioma Oncostream Dynamics: Unraveling Formation, Stability, and Disassembly PathwaysSemantic proximity Read

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathwaySemantic proximity Read