Article

A human iPSC-based neural spheroid platform for modeling glioblastoma infiltration using high-content imaging

2025-10-06

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma is the most aggressive adult brain tumor, characterized by resistance to therapy and high recurrence due to diffuse infiltration. To mimic glioblastoma migration, we developed a physiologically relevant co-culture model, combining patient-derived glioblastoma cell lines with cortical-like neural spheroids differentiated from human induced pluripotent stem cells. Using high-...

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Literature Corpus work: f4867fe1-7176-5001-950e-0a69c823b096
DOI: 10.21203/rs.3.rs-7536545/v1

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