Article

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathway

2020-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma multiforme (GBM) is the most commonly diagnosed brain cancer in adults, characterized by rapid proliferation and aggressive invasion into the stroma. Advances in our understanding of the molecular subtypes of GBM have provided attractive druggable targets. However, the high degree of heterogeneity both among patients and within individual tumors has proven a significant challenge fo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c535a12-6434-56d5-a363-31f786ceda38
DOI: 10.1101/2020.07.16.207233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Patient-derived glioblastoma cells (GBM) exhibit distinct biomechanical profiles associated with altered activity in the cytoskeleton regulatory pathwayDOI 10.1101/2020.07.16.207233Read

Single-cell mechanical analysis reveals viscoelastic similarities between normal and neoplastic brain cellsSemantic proximity Read

Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in GlioblastomaSemantic proximity Read

Cell migration simulator-based biomarkers for glioblastomaSemantic proximity Read

Mechanotherapeutic Potential of Survivin in GlioblastomaSemantic proximity Read

Galectin-1 identifies a unique subpopulation of highly invasive glioblastoma cells and enables their migrationSemantic proximity Read

Impact of the biophysical features of a 3D gelatin microenvironment on glioblastoma malignancy.Semantic proximity Read

Glioblastoma cells use an integrin- and CD44-mediated motor-clutch mode of migration in brain tissueSemantic proximity Read

Mechanosensitive expression of the mesenchymal subtype marker Connective Tissue Growth Factor in GlioblastomaSemantic proximity Read

Traction force dynamics during patient-derived glioblastoma neurosphere invasion in 3D MatrigelSemantic proximity Read

Glioblastoma Cells Use an Integrin- and CD44-Mediated Motor-Clutch Mode of Migration in Brain TissueSemantic proximity Read

Lamins regulate nuclear mechanics and shape to control glioblastoma cell proliferation, migration and invasionSemantic proximity Read

Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamicsSemantic proximity Read