Article
Differential migration mechanics and immune responses of glioblastoma subtypes
2022-06-29
Abstract excerpt
Glioblastoma remains a deadly cancer driven in part by invasion of tumor cells into the brain. Transcriptomic analyses have identified distinct molecular subtypes, but mechanistic differences that account for clinical differences are not clear. Here, we show that, as predicted by the motor-clutch model of cell migration, mesenchymal glioma cells are more spread, generate larger traction forces, and migrate faster...
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Identifiers and source
- Literature Corpus work
- 33f12e67-96bf-56e9-a9ad-d5b6cca28693
- DOI
- 10.1101/2022.06.26.497270