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Article

<i>Ex vivo</i> dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes

2018-09-03

Abstract excerpt

The perivascular niche (PVN) plays an essential role in brain tumor stem-like cell (BTSC) fate control, tumor invasion, and therapeutic resistance. Herein we report on the use of a microvasculature-on-a-chip system as a PVN model to evaluate the dynamics of BTSCs ex vivo from 10 glioblastoma patients. We observed that BTSCs preferentially localize in the perivascular zone. Live cell tracking revealed that the cel...

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Identifiers and source

Literature Corpus work
c29c30cd-8453-56f1-a1dc-f7e9200f3968
DOI
10.1101/400739
Open publication

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<i>Ex vivo</i> dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypesDOI 10.1101/400739
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