Article

Adaptation to High Altitude: Phenotypes and Genotypes

2014-07-25

Abstract excerpt

Populations residing for millennia on the high-altitude plateaus of the world started natural experiments that we can evaluate to address questions about the processes of evolution and adaptation. A 2001 assessment in this journal summarized abundant evidence that Tibetan and Andean high-altitude natives had different phenotypes, and the article made a case for the hypothesis that different genetic bases underlie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77148240-58de-5318-9c83-36f3f1b5d115
DOI: 10.1146/annurev-anthro-102313-030000

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adaptation to High Altitude: Phenotypes and GenotypesDOI 10.1146/annurev-anthro-102313-030000Read

Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.Semantic proximity Read

Andean and Tibetan patterns of adaptation to high altitude.Semantic proximity Read

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.Semantic proximity Read

Genetic determinants of Tibetan high-altitude adaptation.Semantic proximity Read

Genetic adaptation to high altitude in the Ethiopian highlands.Semantic proximity Read

The genetic architecture of adaptations to high altitude in Ethiopia.Semantic proximity Read

Genetics of human origin and evolution: high-altitude adaptations.Semantic proximity Read

Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude AdaptationSemantic proximity Read

Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.Semantic proximity Read

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.Semantic proximity Read

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.Semantic proximity Read

Population History and Altitude-Related Adaptation in the SherpaSemantic proximity Read