Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Apr 2014

Petousi Nayia, Robbins Peter A

Abstract excerpt

The Tibetan Plateau is one of the highest regions on Earth. Tibetan highlanders are adapted to life and reproduction in a hypoxic environment and possess a suite of distinctive physiological traits. Recent studies have identified genomic loci that have undergone natural selection in Tibetans. Two of these loci, EGLN1 and EPAS1, encode major components of the hypoxia-inducible factor transcriptional system, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acclimatization
Share to Altitude
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomics

Share to Hypoxia

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 24201705
DOI: 10.1152/japplphysiol.00605.2013
PMCID: PMC3972749

Genes

EGLN1
EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era.PMID 24201705Read ↗

Genetic determinants of Tibetan high-altitude adaptation.Semantic proximity Read ↗

Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.Semantic proximity Read ↗

Andean and Tibetan patterns of adaptation to high altitude.Semantic proximity Read ↗

Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia.Semantic proximity Read ↗

HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans.Semantic proximity Read ↗

Genetic evidence for high-altitude adaptation in Tibet.Semantic proximity Read ↗

Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation.Semantic proximity Read ↗

Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations.Semantic proximity Read ↗

Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia.Semantic proximity Read ↗

A Genome-Wide Search for Signals of High-Altitude Adaptation in TibetansSemantic proximity Read ↗

Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.Semantic proximity Read ↗

Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.