Article
Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2010
Beall Cynthia M, Cavalleri Gianpiero L, Deng Libin, Elston Robert C, Gao Yang, Knight Jo, Li Chaohua, Li Jiang Chuan, Liang Yu, McCormack Mark, Montgomery Hugh E, Pan Hao, Robbins Peter A, Shianna Kevin V, Tam Siu Cheung, Tsering Ngodrop, Veeramah Krishna R, Wang Wei, Wangdui Puchung, Weale Michael E, Xu Yaomin, Xu Zhe, Yang Ling, Zaman M Justin, Zeng Changqing, Zhang Li, Zhang Xianglong, Zhaxi Pingcuo, Zheng Yong Tang
Abstract excerpt
By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection. We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide a...
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