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Article

Genetics of human origin and evolution: high-altitude adaptations.

Current opinion in genetics & development - 1 Dec 2016

Bigham Abigail W

Abstract excerpt

High altitude, defined as elevations lying above 2500m sea level, challenges human survival and reproduction. This environment provides a natural experimental design wherein specific populations, Andeans, Ethiopians, and Tibetans, have lived in a chronic hypoxia state for millennia. These human groups have overcome the low ambient oxygen tension of high elevation via unique physiologic and genetic adaptations....

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Share to Adaptation, Physiological
Share to Altitude
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Hypoxia

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Selection, Genetic

Source

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Identifiers

PMID: 27501156
DOI: 10.1016/j.gde.2016.06.018
PMCID: PMC5161537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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