Article
Genetic adaptation to high altitude in the Ethiopian highlands.
Genome biology - 20 Jan 2012
Scheinfeldt Laura B, Soi Sameer, Thompson Simon, Ranciaro Alessia, Woldemeskel Dawit, Beggs William, Lambert Charla, Jarvis Joseph P, Abate Dawit, Belay Gurja, Tishkoff Sarah A
Abstract excerpt
BACKGROUND: Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, including EPAS1, EGLN1, and PPARA, which play a role in the HIF-1 pathway. Here, we have extended this work to high- and low-altitude populations living in Ethiopia,...
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