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Article

The genetic architecture of adaptations to high altitude in Ethiopia.

PLoS genetics - 1 Jan 2012

Alkorta-Aranburu Gorka, Beall Cynthia M, Witonsky David B, Gebremedhin Amha, Pritchard Jonathan K, Di Rienzo Anna

Abstract excerpt

Although hypoxia is a major stress on physiological processes, several human populations have survived for millennia at high altitudes, suggesting that they have adapted to hypoxic conditions. This hypothesis was recently corroborated by studies of Tibetan highlanders, which showed that polymorphisms in candidate genes show signatures of natural selection as well as well-replicated association signals for...

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Share to Acclimatization
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Share to Altitude Sickness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23236293
DOI: 10.1371/journal.pgen.1003110
PMCID: PMC3516565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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