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Article

Genetic determinants of Tibetan high-altitude adaptation.

Human genetics - 1 Apr 2012

Simonson Tatum S, McClain Donald A, Jorde Lynn B, Prchal Josef T

Abstract excerpt

Some highland populations have genetic adaptations that enable their successful existence in a hypoxic environment. Tibetans are protected against many of the harmful responses exhibited by non-adapted populations upon exposure to severe hypoxia, including elevated hemoglobin concentration (i.e., polycythemia). Recent studies have highlighted several genes subject to natural selection in native high-altitude...

Read the complete abstract on PubMed

Topics

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Share to Adaptation, Physiological
Share to Altitude
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Hypoxia-Inducible Factor-Proline Dioxygenases

Share to PPAR alpha

Share to Procollagen-Proline Dioxygenase

Source

Identifiers

PMID: 22068265
DOI: 10.1007/s00439-011-1109-3

Genes

EGLN1
EPAS1
PPARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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