Article

A Phage-Assisted Continuous Selection Approach for Deep Mutational Scanning of Protein-Protein Interactions

2019-08-19

Abstract excerpt

Protein-protein interactions (PPIs) are critical for organizing molecules in a cell and mediating signaling pathways. Dysregulation of PPIs are often key drivers of disease. To better understand the biophysical basis of such disease processes – and to potentially target them - it is critical to understand the molecular determinants of PPIs. Deep mutational scanning (DMS) facilitates the acquisition of large amount...

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Literature Corpus work: 76fb07ca-9db3-59e8-9626-b8213fb94653
DOI: 10.26434/chemrxiv.9642830.v1

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