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Article

A conformation-selective protein binder for a KRAS mutant inhibits the interaction between RAS and RAF.

Biochemical and biophysical research communications - 19 Feb 2023

Jung Youn Hee, Choi Yoonjoo, Seo Hyo-Deok, Seo Moon-Hyeong, Kim Hak-Sung

Abstract excerpt

Small GTPases are key signaling nodes that regulate the cellular processes and subcellular events, and their abnormal activities and dysregulations are closely linked with diverse cancers. Here, we report the development of conformation-selective protein binders for a KRAS mutant. The conformation-specific protein binders were selected from a repebody scaffold composed of LRR (Leucine-rich repeat) modules through...

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Identifiers

PMID: 36682330
DOI: 10.1016/j.bbrc.2023.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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