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Article

The energetic and allosteric landscape for KRAS inhibition.

Nature - 1 Feb 2024

Weng Chenchun, Faure Andre J, Escobedo Albert, Lehner Ben

Abstract excerpt

Thousands of proteins have been validated genetically as therapeutic targets for human diseases1. However, very few have been successfully targeted, and many are considered 'undruggable'. This is particularly true for proteins that function via protein-protein interactions-direct inhibition of binding interfaces is difficult and requires the identification of allosteric sites. However, most proteins have no known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38109937
DOI: 10.1038/s41586-023-06954-0
PMCID: PMC10866706

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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