Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display.

Abstract excerpt

Protein engineering using display platforms such as yeast display and phage display has allowed discovery of proteins with therapeutic and industrial applications. Antibodies and T cell receptors developed for therapeutic applications are often engineered by constructing libraries of mutations in loops of five to ten residues called complementarity determining regions that are in proximity to the antigen. In the...

Topics

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• Mutagenesis
• Mutation
• Protein Engineering
• Receptors, Antigen, T-Cell
• Saccharomyces cerevisiae