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Article

Deep mutational scanning: assessing protein function on a massive scale.

Trends in biotechnology - 1 Sept 2011

Araya Carlos L, Fowler Douglas M

Abstract excerpt

Analysis of protein mutants is an effective means to understand their function. Protein display is an approach that allows large numbers of mutants of a protein to be selected based on their activity, but only a handful with maximal activity have been traditionally identified for subsequent functional analysis. However, the recent application of high-throughput sequencing (HTS) to protein display and selection...

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Identifiers

PMID: 21561674
DOI: 10.1016/j.tibtech.2011.04.003
PMCID: PMC3159719

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