Article

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

2023-09-18

Abstract excerpt

Whole genome and exome sequencing are reporting on hundreds of thousands of missense mutations. Taking a pan-disease approach, we explored how mutations in the intrinsically disordered regions (IDRs) break or generate protein interactions mediated by short linear motifs. We created a peptide-phage display library tiling ∼57,000 peptides from the IDRs of the human proteome overlapping 12,301 single nucleotide varia...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 396498da-c94f-5d3a-bbbe-c5d2342049fd
DOI: 10.1101/2023.09.18.558189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteome-scale characterisation of motif-based interactome rewiring by disease mutationsDOI 10.1101/2023.09.18.558189Read

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.Semantic proximity Read

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteomeSemantic proximity Read

An Atlas of Short Linear Motif-Mediated Human Protein-Protein InteractionsSemantic proximity Read

ProP-PD for proteome-wide motif-mediated interaction discoverySemantic proximity Read

How mutations of intrinsically disordered protein regions can drive cancerSemantic proximity Read

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.Semantic proximity Read

High-throughput methods for identification of protein-protein interactions involving short linear motifsSemantic proximity Read

A proteome-wide dependency map of protein interaction motifsSemantic proximity Read

Prediction and experimental characterization of nsSNPs altering human PDZ-binding motifs.Semantic proximity Read

A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.Semantic proximity Read

A proteome-wide dependency map of protein interaction motifs.Semantic proximity Read

Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?Semantic proximity Read