Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.

doi:10.1002/alz.14402

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Article

Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2025

Yu Zhong-Yuan, Liu Jie, Liu Zhi-Hao, Liu Xiao-Yu, Tuo Jin-Mei, Li Jiang-Hui, Tu Yun-Feng, Tan Qi, Ma Yuan-Yuan, Bai Yu-Di, Xin Jia-Yan, Huang Shan, Zeng Gui-Hua, Shi An-Yu, Wang Jun, Liu Yu-Hui, Bu Xian-Le, Ye Li-Lin, Wan Ying, Liu Tong-Fei, Chen Xiao-Wei, Qiu Zi-Long, Gao Chang-Yue, Wang Yan-Jiang

Abstract excerpt

INTRODUCTION: The triggering receptor expressed on myeloid cells 2 (TREM2) arginine-47-histidine (R47H) mutation is a significant risk for Alzheimer's disease (AD) with unclear mechanisms. Previous studies focused on microglial amyloid-β (Aβ) phagocytosis with less attention on the impact of TREM2R47H mutation on blood monocytes. METHODS: Bone marrow transplantation (BMT) models were used to assess the...

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PMID: 39740209
DOI: 10.1002/alz.14402
PMCID: PMC11848385

Genes

APP
TREM2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Roles of blood monocytes carrying TREM2R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.PMID 39740209Read ↗

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