Article

Mechanisms of increased Alzheimer’s Disease pathology with <i>R47H</i> and <i>R62H TREM2</i> variants

2022-07-13

Abstract excerpt

TREM2 plays multiple functional roles in microglia and variants are associated with increased risks of Alzheimer’s disease (AD). Genetic polymorphisms reducing expression of the functionally related protein CD33 are protective. Here we have contrasted cellular pathology in human post-mortem brain with and without AD to test mechanisms associated with the differential genetic risks conferred by R47H and R62H TRE...

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Literature Corpus work: 154609e0-f3a1-5be1-bf77-83d6c0a707cf
DOI: 10.1101/2022.07.12.22277509

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