Article
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.
Nature genetics - 1 May 2021
Eales James M, Jiang Xiao, Xu Xiaoguang, Saluja Sushant, Akbarov Artur, Cano-Gamez Eddie, McNulty Michelle T, Finan Christopher, Guo Hui, Wystrychowski Wojciech, Szulinska Monika, Thomas Huw B, Pramanik Sanjeev, Chopade Sandesh, Prestes Priscilla R, Wise Ingrid, Evangelou Evangelos, Salehi Mahan, Shakanti Yusif, Ekholm Mikael, Denniff Matthew, Nazgiewicz Alicja, Eichinger Felix, Godfrey Bradley, Antczak Andrzej, Glyda Maciej, Król Robert, Eyre Stephen, Brown Jason, Berzuini Carlo, Bowes John, Caulfield Mark, Zukowska-Szczechowska Ewa, Zywiec Joanna, Bogdanski Pawel, Kretzler Matthias, Woolf Adrian S, Talavera David, Keavney Bernard, Maffia Pasquale, Guzik Tomasz J, O'Keefe Raymond T, Trynka Gosia, Samani Nilesh J, Hingorani Aroon, Sampson Matthew G, Morris Andrew P, Charchar Fadi J, Tomaszewski Maciej
Abstract excerpt
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and antihypertensive treatment. However, genetically mediated renal mechanisms underlying susceptibility to hypertension remain poorly understood. We integrated genotype, gene expression, alternative splicing and DNA methylation profiles of up to 430 human kidneys to characterize the effects of BP index variants from...
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