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Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis

23 Apr 2025

Abstract excerpt

Background: At present, there are still limitations and challenges in the treatment of hyperuricemia (HUA). Mendelian randomization (MR) has been widely used to identify new therapeutic targets. Therefore, we conducted a systematic druggable genome-wide MR to explore potential therapeutic targets and drugs for HUA. Methods: We integrated druggable genome data; blood, kidney, and intestinal expression quantitative...

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Share to Alcohol Consumption and Health Effects
Share to Gout, Hyperuricemia, Uric Acid
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PMID: 40426853
DOI: 10.3390/biomedicines13051022

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