Article

A genome-wide association analysis of 2,622,830 individuals reveals new pathogenic pathways in gout

2022-11-29

Abstract excerpt

Gout is a chronic disease of monosodium urate crystal deposition in the setting of hyperuricemia that typically presents with recurrent flares of acute inflammatory arthritis that occur due to innate immune response to deposited crystals. The molecular mechanism of the progression from hyperuricemia to clinical gout is poorly understood. Here we provide insights into this progression from a genetic study of 2.6 mi...

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Literature Corpus work: 48b9878e-0e93-539e-b24b-7d45d02635cc
DOI: 10.1101/2022.11.26.22281768

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