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Functional characterization of the disease-associated <i>CCL2</i> rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuR

2023-11-02

Abstract excerpt

CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles: A>G; G is the risk allele) polymorphism in the CCL2 cis -regulatory region is associated with increased CCL2 expression in vitro and ex vivo, leukocyte mobilization in vivo...

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Literature Corpus work
76c90ad4-6aec-589b-b9b3-17d11b5773b6
DOI
10.1101/2023.10.31.564937
Open publication

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Functional characterization of the disease-associated <i>CCL2</i> rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuRDOI 10.1101/2023.10.31.564937
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