Article
Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model.
Cell reports - 29 Aug 2023
Liu Zhenqing, Chao Jianfei, Wang Cheng, Sun Guihua, Roeth Daniel, Liu Wei, Chen Xianwei, Li Li, Tian E, Feng Lizhao, Davtyan Hayk, Blurton-Jones Mathew, Kalkum Markus, Shi Yanhong
Abstract excerpt
The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer's disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what the underlying mechanisms are remain unclear. In this study, the CLU rs11136000 SNP is identified as a functional variant by a small-scale CRISPR-Cas9 screen. Astrocytes derived...
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