Article

Rare damaging <i>CCR2</i> variants are associated with lower lifetime cardiovascular risk

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human atherosclerotic cardiovascular disease. <h4>Methods</h4> Computationally predicted damaging or loss-of-function (REVEL>0.5) variants within CCR2 were d...

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Literature Corpus work: 6628cb7c-9544-575d-a1f3-607e6106d3e9
DOI: 10.1101/2023.08.14.23294063

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