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Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer’s disease

11 Apr 2023

Abstract excerpt

TREM2 encoding the transmembrane receptor protein TREM2 is a risk gene of Alzheimer's disease (AD), and the impairment of TREM2 functions in microglia due to mutations in TREM2 may significantly increase the risk of AD by promoting AD pathologies. However, how the expression of TREM2 is regulated and the transcription factors required for TREM2 expression are largely unknown. By luciferase assay, DNA pull-down,...

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PMID: 37044212
DOI: 10.1016/j.jbc.2023.104688

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