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Article

Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC-Binding Factor and YY1 Binding.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2022

Gopalakrishnan Jaanam, Tessneer Kandice L, Fu Yao, Pasula Satish, Pelikan Richard C, Kelly Jennifer A, Wiley Graham B, Gaffney Patrick M

Abstract excerpt

OBJECTIVE: Genetic variants spanning UBE2L3 are associated with increased expression of the UBE2L3-encoded E2 ubiquitin-conjugating enzyme H7 (UbcH7), which facilitates activation of proinflammatory NF-κB signaling and susceptibility to autoimmune diseases. We undertook this study to delineate how genetic variants carried on the UBE2L3/YDJC autoimmune risk haplotype function to drive hypermorphic UBE2L3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34279042
DOI: 10.1002/art.41925
PMCID: PMC8712360

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