The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance.

doi:10.1371/journal.pone.0049498

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Article

The rs1024611 regulatory region polymorphism is associated with CCL2 allelic expression imbalance.

PloS one - 1 Jan 2012

Pham Minh-Hieu T, Bonello Gregory B, Castiblanco John, Le Tuan, Sigala Jose, He Weijing, Mummidi Srinivas

Abstract excerpt

CC chemokine ligand 2 (CCL2) is the most potent monocyte chemoattractant and inter-individual differences in its expression level have been associated with genetic variants mapping to the cis-regulatory regions of the gene. An A to G polymorphism in the CCL2 enhancer region at position -2578 (rs1024611; A>G), was found in most studies to be associated with higher serum CCL2 levels and increased susceptibility to...

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Identifiers

PMID: 23166687
DOI: 10.1371/journal.pone.0049498
PMCID: PMC3500309

Genes

CCL2

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