Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.

doi:10.1093/hmg/ddu106

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Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.

Human molecular genetics - 1 Aug 2014

Maiti Amit K, Kim-Howard Xana, Motghare Prasenjeet, Pradhan Vandana, Chua Kek Heng, Sun Celi, Arango-Guerrero María Teresa, Ghosh Kanjaksha, Niewold Timothy B, Harley John B, Anaya Juan-Manual, Looger Loren L, Nath Swapan K

Abstract excerpt

Integrin alpha M (ITGAM; CD11b) is a component of the macrophage-1 antigen complex, which mediates leukocyte adhesion, migration and phagocytosis as part of the immune system. We previously identified a missense polymorphism, rs1143679 (R77H), strongly associated with systemic lupus erythematosus (SLE). However, the molecular mechanisms of this variant are incompletely understood. A meta-analysis of published and...

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Identifiers

PMID: 24608226
DOI: 10.1093/hmg/ddu106
PMCID: PMC4082363

Genes

ITGAM
EBF1
NFKB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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