Article
Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1.
Science advances - 1 Feb 2018
Palstra Robert-Jan, de Crignis Elisa, Röling Michael D, van Staveren Thomas, Kan Tsung Wai, van Ijcken Wilfred, Mueller Yvonne M, Katsikis Peter D, Mahmoudi Tokameh
Abstract excerpt
We integrated data obtained from HIV-1 genome-wide association studies with T cell-derived epigenome data and found that the noncoding intergenic variant rs4349147, which is statistically associated with HIV-1 acquisition, is located in a CD4+ T cell-specific deoxyribonuclease I hypersensitive region, suggesting regulatory potential for this variant. Deletion of the rs4349147 element in Jurkat cells strongly...
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