The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype.

doi:10.7554/eLife.93108

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Article

The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype.

eLife - 14 Jan 2026

Akhtar Feroz, Ruiz Joselin Hernandez, Liu Ya-Guang, Resendez Roy G, Feliers Denis, Morales Liza D, Diaz-Badillo Alvaro, Lehman Donna M, Arya Rector, Alvarenga Juan Carlos Lopez, Blangero John, Duggirala Ravindranath, Mummidi Srinivas

Abstract excerpt

CC-chemokine ligand 2 (CCL2) is involved in the pathogenesis of several diseases associated with monocyte/macrophage recruitment, such as HIV-associated neurocognitive disorder (HAND), tuberculosis, and atherosclerosis. The rs1024611 (alleles: A>G; G is the risk allele) polymorphism in the CCL2 cis-regulatory region is associated with increased CCL2 expression in vitro and ex vivo, leukocyte mobilization in vivo,...

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PMID: 41533455
DOI: 10.7554/eLife.93108
PMCID: PMC12803514

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CCL2

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