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Distinct patterns of somatic genomic alterations and mutational signatures in central and peripheral-type small-cell lung cancer

1 Apr 2021

Abstract excerpt

Background: Generally, small-cell lung cancer (SCLC) can be classified into central and peripheral-type. Genomic landscape and genetic heterogeneity between central and peripheral-type SCLCs is scarce.Methods: We conducted whole-exome sequencing (WES) of 41 tumor/control pairs of SCLC samples. In all cases, 8,186 genes with non-synonymous mutations were identified, as well as significantly mutated genes (SMGs),...

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PMID: 34012790
DOI: 10.21037/tlcr-20-1096

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