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Article

Molecular subtyping of small-cell lung cancer based on mutational signatures with different genomic features and therapeutic strategies.

Cancer science - 1 Feb 2023

Wang Haiyong, Wu Shuangxiu, Li Zhenzhen, Zhang Chenyue, Shang Xiaoling, Zhao Chenglong, Li Zhenxiang, Lin Jiamao, Guo Jun, Wang Zhehai

Abstract excerpt

Small-cell lung cancer (SCLC) is an exceptionally lethal malignancy characterized by extremely high alteration rates and tumor heterogeneity, which limits therapeutic options. In contrast to non-small-cell lung cancer that develops rapidly with precision oncology, SCLC still remains outside the realm of precision medicine. No recurrent and actionable mutations have been detected. Additionally, a paucity of...

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Identifiers

PMID: 36178064
DOI: 10.1111/cas.15606
PMCID: PMC9899606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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